through Logandale and Overton - including as it curves. Continue to follow NV-169/Moapa Valley Blvd. In town, NV Hwy 169 becomes Moapa Valley Blvd.
Overton is approximately 11 miles south-east of I-15 on NV Hwy 169. Overton can be reached from Las Vegas by traveling North on I-15 for approximately 55 miles and taking Exit 93 - NV Hwy 169 - towards Logandale/Overton. The mostly unpaved road to Double Negative is most easily traveled from Overton.
Assuming no traffic, we estimate approximately 90 minutes for the journey, each way. Though the highway travel proceeds quickly, you will want to proceed slowly through town and on the dirt roads. Using the directions below, Double Negative is approximately 75 miles from the Las Vegas Strip. We recommend that you bring extra water and wear sturdy walking shoes. Some walking in rocky, sandy terrain is required, so you should be prepared for exposure to desert temperatures, which in the summer can run up to 120 degrees. We therefore encourage you to either print these directions or pull them up on your cell phone while in Overton, to ensure that they will be available offline. It can be very easy to become disoriented on the mesa, particularly given the numerous unpaved roads, and a cell phone signal may not be available. Reliable directions to Double Negative can be hard to come by, even from locals in Overton or via Google Maps. The journey requires travel on unpaved, rocky roads, so a vehicle with high clearance and good tires is highly recommended. In that the artwork is itself negative space (and when it crosses empty space, it is doubly negative space, as the title suggests), it begs meditation on the principle of art as creation, when Heizer has not in fact added but subtracted.ĭouble Negative belongs to The Museum of Contemporary Art, Los Angeles, through the gift of Virginia Dwan.ĭouble Negative is located in a rather remote area of the Nevada desert, but it can be visited relatively easily from Las Vegas. Constructing Double Negative was an act of "construction" only inasmuch as something was taken away, and that this removal constituted a creative act. In that, it consists more of what was than what currently is. How does art change when it can't fit in a museum? How does one observe an artwork that's a quarter-mile long?ĭouble Negative, though a notable piece of art, is essentially no more than a big trench (and even then, not a complete trench, as it crosses empty space). The sheer size of Double Negative also invites contemplation of the scale of art, and the relation of the viewer the earth and to art itself.
In keeping with the mission of modern art, Double Negative blurs the distinction between sculpture ("art") and normal objects such as rocks ("not art"), and encourage viewers to consider how the earth relates to art. Finally, we will examine DN T cells as promising therapeutic targets to prevent or inhibit human disease development.Ĭancer double-negative T cells immunoregulation inflammatory diseases parasitic diseases.Double Negative was among the first "earthworks" - artworks that use as their canvas or medium the earth itself. The need for developing biomarkers to facilitate the translation of studies from animal models to humans will also be discussed. Here, we review phenotypic and functional characteristics of DN T cells, emphasizing their role in human diseases. This apparent contradiction highlighted the heterogeneity of the DN T-cell population.
However, other studies demonstrated that these cells can also display effector functions associated with pathology development. DN T cells were initially associated with induction of peripheral immunological tolerance and immunomodulatory activities related to disease prevention. Despite their low frequencies, these cells are potent producers of cytokines and, thus, are key orchestrators of immune responses. Double-negative (DN) T cells are present at relatively low frequencies in human peripheral blood, and are characterized as expressing the alpha-beta or gamma-delta T-cell receptor (TCR), but not the CD4 nor the CD8 co-receptors.
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